abstract：PURPOSE:To determine whether multivariate machine learning models of algorithmically assessed magnetic resonance imaging (MRI) features from breast cancer patients are associated with Oncotype DX (ODX) test recurrence scores. METHODS:A set of 261 female patients with invasive breast cancer, pre-operative dynamic contr...

journal_title：Journal of cancer research and clinical oncology

authors： Saha A,Harowicz MR,Wang W,Mazurowski MA

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4-10 ng/ml. METHODS:We retrospectively reviewed multi-parameter magnetic resonance images from 528 patients with PSA levels...

journal_title：Journal of cancer research and clinical oncology

authors： Xu N,Wu YP,Chen DN,Ke ZB,Cai H,Wei Y,Zheng QS,Huang JB,Li XD,Xue XY

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The role of somatic BRCA1/2 gene mutations in breast cancer is getting increasing attention in view of hereditary disease. The medullary phenotype and triple negative intrinsic subtypes are often, but not exclusively encountered in BRCA1 germline mutated breast cancer, whilst for BRCA2, no association to spe...

journal_title：Journal of cancer research and clinical oncology

authors： Rechsteiner M,Dedes K,Fink D,Pestalozzi B,Sobottka B,Moch H,Wild P,Varga Z

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:In our previous global gene expression analysis, we identified NIPA-like domain containing 1 (NIPAL1), which encodes a magnesium transporter, as one of the most overexpressed genes in recurrent oral squamous cell carcinoma (OSCC). Although has been NIPAL1 linked with gout pathogenesis, little is known about its...

journal_title：Journal of cancer research and clinical oncology

authors： Sasahira T,Nishiguchi Y,Kurihara-Shimomura M,Nakashima C,Kuniyasu H,Kirita T

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the frequency of second primary non-breast cancer after breast cancer diagnosis and treatment, and its correlation with clinicopathological features. METHODS:Data from 21,527 patients with primary breast cancer were collected retrospectively in a single cancer centre; 4.1% o...

journal_title：Journal of cancer research and clinical oncology

authors： Corso G,Veronesi P,Santomauro GI,Maisonneuve P,Morigi C,Peruzzotti G,Intra M,Sacchini V,Galimberti V

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Trimodal therapy is a reasonable bladder-preserving option to radical cystectomy. However, many tumors are radioresistive. In this sense, the identification of new prognostic and predictive biomarkers that allow the selection of patients with better responses to radiation therapy would improve outcomes. With th...

journal_title：Journal of cancer research and clinical oncology

authors： Dietrich F,Figueiró F,Filippi-Chiela EC,Cappellari AR,Rockenbach L,Tremblay A,de Paula PB,Roesler R,Filho AB,Sévigny J,Morrone FB,Battastini AMO

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the prognostic significance of the absolute natural killer (NK) cell counts in peripheral blood in patients with chronic lymphocytic leukemia (CLL). METHODS:A total of 273 previously untreated patients with CLL from April 2004 and October 2015 were enrolled into this re...

journal_title：Journal of cancer research and clinical oncology

authors： Wang WT,Zhu HY,Wu YJ,Xia Y,Wu JZ,Wu W,Liang JH,Wang L,Fan L,Li JY,Xu W

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects...

journal_title：Journal of cancer research and clinical oncology

authors： Lowe NM,Bernstein JM,Mais K,Garcez K,Lee LW,Sykes A,Thomson DJ,Homer JJ,West CM,Slevin NJ

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:B-cell translocation gene 3 (BTG3) has been identified as a candidate driver gene for various cancers, but its specific role in colorectal cancer (CRC) is poorly understood. We aimed to investigate the relationship between expression of BTG3 and clinicopathological features and prognosis, as well as to explore ...

journal_title：Journal of cancer research and clinical oncology

authors： Lv C,Wang H,Tong Y,Yin H,Wang D,Yan Z,Liang Y,Wu D,Su Q

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:A disintegrin and metalloprotease with motif 5(ADAMTS5) has been involved in colorectal cancer (CRC) with hypermethylation in the promoter. However, its role in CRC remains unclear. The aim of this study was to explore the clinical significance and biological effect of ADAMTS5 on colorectal carcinogenesis. Thro...

journal_title：Journal of cancer research and clinical oncology

authors： Li J,Liao Y,Huang J,Sun Y,Chen H,Chen C,Li S,Yang Z

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Evidence shows that exon 19 deletions (19del) and exon 21 Leu858Arg point mutation (L858R) of EGFR are different in response to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in advanced lung cancers. However, the impact of the two mutational types in the early stage lung adenocarcinoma is unknown. MET...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang Y,Ma Y,Li Y,Shen X,Yu Y,Pan Y,Zhang Y,Yu S,Zheng D,Zhao Y,Hu H,Sun Y,Zhang Y,Xiang J,Chen H

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Prostate cancer is one of the leading causes of cancer death for male. In the present study, we applied an integrated bioinformatics approach to provide a novel perspective and identified some hub genes of prostate cancer. METHOD:Microarray data of fifty-nine prostate cancer were downloaded from Gene Expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Huang H,Zhang Q,Ye C,Lv JM,Liu X,Chen L,Wu H,Yin L,Cui XG,Xu DF,Liu WH

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To examine the associations between modifiable health-related factors, such as smoking, low physical activity and higher body mass index (BMI), and annual health care visits and expenditures among adult cancer survivors in the United States. METHODS:Using data from the 2010-2014 Medical Expenditures Panel Su...

journal_title：Journal of cancer research and clinical oncology

authors： Kaul S,Avila JC,Jupiter D,Rodriguez AM,Kirchhoff AC,Kuo YF

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. In the past few years, the discovery of inter-genomic crosstalk between nucleus and mitochondria has reinforced the role of mitochondrial DNA variants in perturbing thi...

journal_title：Journal of cancer research and clinical oncology

authors： Errichiello E,Venesio T

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Despite great progress in the diagnosis and treatment of localized prostate cancer (PCa), there remains a need for new diagnostic markers that can accurately distinguish indolent and aggressive variants. One promising approach is the antibody-based targeting of prostate stem cell antigen (PSCA), which is freque...

journal_title：Journal of cancer research and clinical oncology

authors： Kessler C,Pardo A,Tur MK,Gattenlöhner S,Fischer R,Kolberg K,Barth S

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

journal_title：Journal of cancer research and clinical oncology

authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Metastases are a common event in breast cancer. The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) is essential for therapy and prognosis, and their conversion during disease progression potentially affects the treatment regimen. The aim was...

journal_title：Journal of cancer research and clinical oncology

authors： Nauroth A,Kalder M,Rössler M,Wichmann G,Dietz A,Wiegand S

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Ribonucleotide reductase (RR) enzymes (RR1 and RR2) play an important role in the reduction of ribonucleotides to deoxyribonucleotides which is involved in DNA replication and repair. Augmented RR activity has been ascribed to uncontrolled cell growth and tumorigenic transformation. METHODS:This review mainly ...

journal_title：Journal of cancer research and clinical oncology

authors： Mannargudi MB,Deb S

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Achievement of deep molecular response with a tyrosine kinase inhibitor in patients with chronic myeloid leukemia (CML) is required to attempt discontinuation of therapy in these patients. The current subanalysis from the Evaluating Nilotinib Efficacy and Safety in Clinical Trials as First-Line Treatment (ENEST...

journal_title：Journal of cancer research and clinical oncology

authors： Giles FJ,Rea D,Rosti G,Cross NCP,Steegmann JL,Griskevicius L,le Coutre P,Coriu D,Petrov L,Ossenkoppele GJ,Mahon FX,Saussele S,Hellmann A,Koskenvesa P,Brümmendorf TH,Gastl G,Castagnetti F,Vincenzi B,Haenig J,Hochhaus

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the effectiveness and safety of ultrasound guided percutaneous radiofrequency ablation (RFA) of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma. METHODS:54 metastatic LNs confirmed by percutaneous biopsy in 33 patients with previous total thyroidectomy...

journal_title：Journal of cancer research and clinical oncology

authors： Guang Y,Luo Y,Zhang Y,Zhang M,Li N,Zhang Y,Tang J

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The ENEST1st sub-analysis presents data based on Philadelphia chromosome (Ph) status, i.e., Ph+ and Ph-/BCR-ABL1 + chronic myeloid leukemia. METHODS:Patients received nilotinib 300 mg twice daily, up to 24 months. RESULTS:At screening, 983 patients were identified as Ph+ and 30 patients as Ph-/BCR-ABL + based...

journal_title：Journal of cancer research and clinical oncology

authors： Hochhaus A,Mahon FX,le Coutre P,Petrov L,Janssen JJWM,Cross NCP,Rea D,Castagnetti F,Hellmann A,Rosti G,Gattermann N,Coronel MLP,Gutierrez MAE,Garcia-Gutierrez V,Vincenzi B,Dezzani L,Giles FJ

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies supported the development of molecularly targeted therapy in cancer patients. Thus, genomic analyses are becoming a routine part in clinical practice and accurate detection of actionable mutations is essential to assist diagnosis and therapy choice. However, this is...

journal_title：Journal of cancer research and clinical oncology

authors： Ofner R,Ritter C,Ugurel S,Cerroni L,Stiller M,Bogenrieder T,Solca F,Schrama D,Becker JC

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Explore patient-reported outcomes (PROs), including health-related quality of life (HRQoL), satisfaction with therapy, impact of the therapy on work and daily life, and concerns related to the therapy and identify variables associated with PROs in persons with chronic myeloid leukemia (CML) receiving tyrosine k...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Wang HB,Yu L,Gale RP

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:HepaCAM, an N-linked glycoprotein that encodes a member of the immunoglobulin superfamily, has been reported to be a tumor suppressor gene that mediates diverse cellular bio-functions. Recent studies have shown that the FoxO transcription factors play a pivotal role during cancer progression. Here, we explored ...

journal_title：Journal of cancer research and clinical oncology

authors： Tang M,Zhao Y,Liu N,Chen E,Quan Z,Wu X,Luo C

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The oncogenic roles of sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, the microRNAs (miRNAs) associated with the oncogenic roles of SphK1 remain largely unknown. METHODS:Global gene and miRNA expression in TPC1-Vector and TPC1-SphK1 cells was an...

journal_title：Journal of cancer research and clinical oncology

authors： Liang W,Xie Z,Cui W,Guo Y,Xu L,Wu J,Guan H

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The therapy for gastrointestinal stromal tumors (GIST) has changed significantly since the use of imatinib mesylate (IM). However, the appropriate duration of receiving adjuvant IM for patients with high-risk GIST who underwent R0 resection is still controversial. METHODS:From January 2005 to December 2014,...

journal_title：Journal of cancer research and clinical oncology

authors： Lin JX,Chen QF,Zheng CH,Li P,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Huang CM

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare...

journal_title：Journal of cancer research and clinical oncology

authors： Sehouli J,Tomè O,Dimitrova D,Camara O,Runnebaum IB,Tessen HW,Rautenberg B,Chekerov R,Muallem MZ,Lux MP,Trarbach T,Gitsch G

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5, which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence, apoptosis, differentiation, angiogenesis, DNA repair, metastasis, and invasion by multiple pathways. In addition, INGs increase cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang R,Jin J,Shi J,Hou Y

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Apatinib, a third-line or later treatment for advanced gastric cancer (aGC), was shown to improve overall survival and progression-free survival (PFS) compared with placebo in the phase III trial. Given the modest benefit with high costs, we further evaluated the cost-effectiveness of apatinib for patients w...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HD,Zhou J,Wen F,Zhang PF,Zhou KX,Zheng HR,Yang Y,Li Q

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Cancer stem cells (CSCs) represent a population with tumour-initiating, self-renewal, and differentiation potential. This study aimed to evaluate the expression patterns and clinical significance of chemokine receptor type 4 (CXCR4) as a novel CSC marker in renal cell carcinoma (RCC). METHODS:The expression of...

journal_title：Journal of cancer research and clinical oncology

authors： Rasti A,Abolhasani M,Zanjani LS,Asgari M,Mehrazma M,Madjd Z

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage...

journal_title：Journal of cancer research and clinical oncology

authors： Du J,Li Y,Lv S,Wang Q,Sun C,Dong X,He M,Ulain Q,Yuan Y,Tuo X,Batchu N,Song Q,Li Q

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Metastasis is a primary cause of colorectal cancer (CRC)-related death, and cancer stem cells (CSCs) are thought to be majorly responsible for initiating metastatic behaviors. Doublecortin-like kinase 1 (DCLK1) was recently discovered to be a marker for gastrointestinal CSCs. Here, we aimed to explore whether D...

journal_title：Journal of cancer research and clinical oncology

authors： Gao T,Wang M,Xu L,Wen T,Liu J,An G

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

journal_title：Journal of cancer research and clinical oncology

authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:The precise determination of energy metabolites is challenged by the heterogeneity of their distribution, their rapid changes after surgical resection and the architectural complexity of malignancies. Induced metabolic bioluminescence imaging (imBI) allows to determine energy metabolites in tissue sections and ...

journal_title：Journal of cancer research and clinical oncology

authors： Battista MJ,Goetze K,Schmidt M,Cotarelo C,Weyer-Elberich V,Hasenburg A,Mueller-Klieser W,Walenta S

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:We examined the influence of OGG1 c.977C>G (rs1052133), APEX1 c.444T>G (rs1130409), XRCC1 c.-77T>C (rs3213245), c.580C>T (rs1799782), c.839G>A (rs25489) and c.1196G>A (rs25487) single-nucleotide polymorphisms (SNPs), involved in base-excision repair (BER) pathway, on oropharyngeal squamous cell carcinoma (OPSCC...

journal_title：Journal of cancer research and clinical oncology

authors： Costa EF,Santos ES,Liutti VT,Leal F,Santos VC,Rinck-Junior JA,Mariano FV,Coutinho-Camillo CM,Altemani A,Lima CS,Lourenço GJ

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Members of paraneoplastic Ma (PNMA) family have been identified as onconeuronal antigens, which aberrant expressions in cancer cells of patients with paraneoplastic disorder (PND) are closely linked to manifestation of auto-immunity, neuro-degeneration, and cancer. The purpose of present study was to determine ...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Poh CL,Tan KO

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:To establish whether women over 65 years of age with newly diagnosed with breast cancer (BC) receive adjuvant chemotherapy less frequently than younger postmenopausal women and whether comorbidity influences this potential undertreatment. MATERIALS AND METHODS:In a single-site, retrospective, comparative study...

journal_title：Journal of cancer research and clinical oncology

authors： Wallwiener CW,Hartkopf AD,Grabe E,Wallwiener M,Taran FA,Fehm T,Brucker SY,Krämer B

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Explore molecular monitoring patterns of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitors therapy in China and identify variables associated with monitoring patterns. METHODS:Non-interventional, cross-sectional study using questionnaires distributed to persons with CML and answered an...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Gale RP

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (LncRNAs) have been demonstrated as playing important roles in diverse biological processes including tumorigenesis. However, the clinical significance and biological function of LncRNA nuclear-enriched abundant transcript 1 (NEAT1) in gastric cancer are still unknown. The aim of this stu...

journal_title：Journal of cancer research and clinical oncology

authors： Fu JW,Kong Y,Sun X

更新日期：2016-07-01 00:00:00